LINC1521 and miR-3679-5p modulate cellular response to chemical stress in breast cancer patients through regulation of XBP1 expression as a potential ...
This study investigates XBP1 and LINC01521 in breast cancer metastasis using GSE71052 microarray data, bioinformatics, miRNA/lncRNA interaction analysis, pathway exploration, and expression and survival analyses to identify potential regulatory mechanisms and biomarkers.
Sayedeh Zahra Shirdeli, Seyedeh Aramdokht Hashemi, Shaghayegh Ferdowsian, Yasaman Mostaghimi, Mohammad Rezaei, Mansoureh Azadeh · October 21, 2026
Background
The majority of breast cancer (BC) patients die of metastasis rather than primary tumors, whereas the molecular mechanisms orchestrating cancer metastasis remains poorly understood. Long noncoding RNAs (lncRNA) have been shown to regulate cancer occurrence and progression. However, the lncRNAs that drive metastasis in cancer patients and their underlying mechanisms are still largely unknown. In this study, expression, interaction, and related pathways of XBP1 and a novel regulatory non-coding RNA, LINC01521 is evaluated in BC patients.
Methods
Microarray data analysis was performed using R Studio (4.1. 2). GSE71052 was used in this study. miRNA interaction analysis carried out using miRWalk. lncRNA-mRNA interaction analysis was conducted using lncRRIsearch. Expression and survival analysis was performed by GEPIA2. Illustration of interaction analyses was performed by …