TP53 rs1625895 is Related to Breast Cancer Incidence and Early Death in Iranian Population
A study of 182 Iranian women found that the TP53 rs1625895 GG genotype was significantly associated with increased breast cancer risk (OR = 6, p = 0.002), suggesting a potential role for this polymorphism in breast cancer susceptibility.
Leila Assad Samani, Seyed-Morteza Javadirad, Soha Parsafar, Hossein Tabatabaeian, Kamran Ghaedi, Mansoureh Azadeh · October 20, 2026
Breast cancer as the second most common cancer worldwide tend to be experienced by Iranian women 10 years earlier with a peak incidence at the premenopausal stage. Genetic mutations of TP53 tumor suppressor gene has been shown to be related to early onset of breast cancer. It has been shown already that rs1625895 polymorphic site is related to glioma as well as lung cancer. In this study, we have investigated the role of rs1625895 polymorphism in breast cancer incidence in Iranian women. DNA extraction of 86 breast cancer patients and 96 control individuals have been used for allele-specific primer-PCR and genotyping of allele A and allele G of the TP53 rs1625895. Genotypes frequencies have been shown that GG homozygosis as the most frequent genotype is a significant association with increased risk of breast cancer development in Iranian women (odds ratio = 6, p = 0.002). On the other …