rs12977 of RAC1 is associated with the progress of gastric cancer in Iranian population
This study investigated the association between the RAC1 rs12977 polymorphism and gastric cancer risk in Iranian patients. Computational analysis explored its potential impact on hsa-miR-3605-3p binding, while HRM-PCR assessed the variant in 140 patients and 54 controls.
Aliasghar Fallahiyan Javani, Mohammad Fazilati, Mansoureh Azadeh, Kamran Ghaedi · October 20, 2026
Gastric Cancer, is widespread despite medical science progress, and is characterized by a low rate of survival and poor recovery of patients throughout the world. Hence, single nucleotide polymorphisms associated with the binding status of miRNA in the target gene that affects gene expression level in this cancer. The purpose of this study was to investigate the association of rs12977 polymorphism alleles in RAC1 and the prevalence of gastric cancer as well as its progress concerning other clinical and pathological features of Iranian patients.
A computational study was initially performed to explore the signaling pathways that correlated with the activity of hsa-miR-3605-3p by way of linking rs12977 was located at its seeding region responsible for the binding with hsa-miR-3605-3p. Real-time PCR-HRM analysis on genomic DNA of stomach cancer (no: 140) and control (no: 54) samples, genotyping approach was …