PLCE1-AS2 and LINC01605 modulate the function of RPGR in the organelle biogenesis signaling pathway in gastric cancer samples
This study investigated PLCE1-AS2 and LINC01605 in gastric cancer using microarray data, bioinformatics, and expression validation. Their target genes, protein interactions, and enriched pathways were analyzed to explore their potential roles as biomarkers and therapeutic targets in gastric cancer.
Zeinab Alimardani, Zahra Zamanzadeh, Morteza Abkar, Mansoureh Azadeh · October 25, 2026
Background
Gastric cancer (GC) represents a significant cause of cancer-related mortality globally, underscoring the pressing need for innovative diagnostic and therapeutic approaches. Long non-coding RNAs (lncRNAs) are increasingly recognized as promising biomarkers due to their pivotal roles in gene expression regulation. This study examines GC specimens' expression and interactions with two novel lncRNAs (PLCE1-AS2 and LINC01605).
Methods
The study utilized microarray analysis (GSE208099) and high-throughput gene expression assessment (ENCORI database) to select and validate novel lncRNAs in GC samples. A lncRNA-mRNA interaction analysis was conducted to identify coding targets of the chosen lncRNAs (lncRRIsearch). The selected lncRNAs' primary target and associated proteins (extracted via STRING) were analyzed using Enrichr to determine related signaling pathways. Validation …