PGR and TUG1 overexpression: a putative diagnostic biomarker in breast cancer patients
This study found significantly elevated PGR and TUG1 expression in breast tumors compared with adjacent normal tissues. ROC analysis suggested their potential diagnostic value, while a significant correlation between their expression indicates a possible regulatory relationship in breast cancer.
Saghar Mashhadizadeh, Mohammad Tavangar, Aliasghar Fallahiyan Javani, Mohamad Davood Rahimian, Mansoureh Azadeh, Hossein Tabatabaeian, Kamran Ghaedi · October 20, 2026
Background
Breast cancer is highly prevalent globally and is one of the main causes of cancer-related deaths worldwide. Despite the advances, more insights are needed to decipher the regulatory mechanisms leading to breast cancer development and progression. Here, we examined the expression of PGR and TUG1 genes in breast cancer.
Material and methods
qPCR was used to quantitatively measure the expression of PGR and TUG1 transcripts in normal and breast cancer fresh clinical samples.
Results
The higher expression of both PGR and TUG1 was observed in the breast tumors as compared to the normal adjacent paired samples. The ROC curve analysis revealed that PGR and TUG1 expression patterns can discriminate breast tumor samples against normal tissues. Besides, there was a significant correlation between PGR and TUG1 expression in the studied samples.
Conclusion
PGR and TUG1 are …