RNA interaction and expression analysis of UHRF1 in breast cancer, gastric cancer, and colorectal cancer patients: systems biology investigation and ...
This study aims to identify novel non-coding RNA biomarkers for breast, gastric, and colorectal cancers, three major global malignancies, to improve understanding of their molecular mechanisms and support the development of potential diagnostic biomarkers.
Dorna Dayani, Simin Sharifi, Seyedeh Solmaz Mohammadi, Masoumeh Ghafourzadeh, Sheida Bahrami, Melika Azaripour, Nasim Karimi, Ali Ghaneh, Sayedeh Zahra Shirdeli, Mohammad Rezaei, Mansoureh Azadeh · October 25, 2026
Background
Breast cancer is the most commonly diagnosed cancer in women and ranks as the second most prevalent cancer globally. The prevalence of gastric cancer (GC) varies substantially between men and women, as well as in different countries. Male rates are two to three times higher than female rates. Colorectal cancer ranks as the third most common cancer globally and is the second leading cause of death related to cancer. In this study, our objective was to identify new non-coding biomarkers for breast cancer, gastric cancer, and colorectal cancer.