Positive association of rs1049694 allele G located in NDRG1 with the incidence of gastric cancer and metastasis
This study investigated the association between the NDRG1 rs1049694 polymorphism and gastric cancer risk in 144 patients and 66 healthy controls. Genotyping was performed using allele-specific primer PCR to assess the potential role of this 3′UTR variant in gastric cancer susceptibility.
Hourasadat Gharazi, Hossein Tabatabaeian, Kamran Ghaedi, Massoud Houshmand, Mansoureh Azadeh · October 20, 2026
Background and purpose
One of the most prevalent cancers in the world and Iran is gastric cancer with a high degree of lethality. There are many environmental factors and genes responsible for gastric cancer incidence. Among genetics factors, NDRG1 has been reported to be associated with the gastric cancer progression, while its single nucleotide polymorphisms (SNPs) have not been widely studied. Among the SNPs, rs1049694 might be of interest as it is located in the 3′UTR of NDRG1 transcripts. However, the relevance of rs1049694 with the incidence of gastric cancer has not been studied yet.
Materials and methods
In this study, 144 patients with gastric cancer and 66 healthy individuals were selected. After taking blood samples and extraction of genomic DNA, genotyping was performed on 1049694 using allele specific primer (ASP)-PCR method. The data were analyzed with the SNPStats and SPSS …