Fluctuating expression of miR-584 in primary and high-grade gastric cancer
This study investigated miR-584 expression in gastric cancer using RT-qPCR, examining its association with H. pylori infection and clinical characteristics, alongside in silico analyses to clarify its potential role in gastric cancer development.
Laleh Ebrahimi Ghahnavieh, Hossein Tabatabaeian, Zhaleh Ebrahimi Ghahnavieh, Mohammad Amin Honardoost, Mansoureh Azadeh, Mohamad Moazeni Bistgani, Kamran Ghaedi · October 20, 2026
Background
Gastric cancer is the fifth most common cancer worldwide. Along with environmental factors, such as Helicobacter pylori (H. pylori) infection, genetic changes play important roles in gastric tumor formations. miR-584 is a less well-characterized microRNA (miRNA), with apparent activity in human cancers. However, miR-584 expression pattern in gastric cancer development has remained unclear. This study aims to analyze the expression of miR-584 in gastric cancer samples and investigates the associations between this miRNA and H. pylori infection and clinical characteristics.
Methods
The expression level of miR-584 was studied in primary gastric cancers versus healthy control gastric mucosa samples using the RT-qPCR method. The clinical data were analyzed statistically in terms of miR-584 expression. In silico studies were employed to study miR-584 more broadly in order to assess its expression …