Upregulation of miR-222 in both Helicobacter pylori-infected and noninfected gastric cancer patients
This study investigated miR-222 expression in gastric cancer tissues and its association with *Helicobacter pylori* infection in 200 patients. It also explored potential miR-222 target genes through in silico analyses to better understand its role in gastric cancer development.
Mina Noormohammad, Samira Sadeghi, Hossein Tabatabaeian, Kamran Ghaedi, Ardeshir Talebi, Mansoureh Azadeh, Mehri Khatami, Mohammad Mehdi Heidari · October 14, 2026
Despite of promising improvements in treatment of gastric cancer, the mortality rate of this malignancy remains high. Chronic infection by Helicobacter pylori, interfering with intracellular signalling pathways, is the main risk factor for gastric cancer. Some evidence suggests that microRNAs (miRNA), the small noncoding RNA molecules, can play role as oncogenes or tumour suppressors in the cells. MiR-222 is one of the remarkable miRNAs undergoing upregulation in gastric cancer. However, the association between miR-222 upregulation and H. pylori infection in gastric cancer tissues remains unclear. The aim of this study was to analyse the expression level of miR-222 in gastric cancer tissues, evaluating the relationship between miR-222 expression level and H. pylori infection and also finding novel miR-222 targets based on in silico investigations. MiR-222 expression level in 200 patients including 112 H …