miR-146a is deregulated in gastric cancer
This study investigated miR-146a expression in gastric cancer tissues and its association with Helicobacter pylori infection and clinical characteristics, using RT-qPCR to assess its potential role in gastric tumorigenesis and inflammation.
Bahareh Adami, Hossein Tabatabaeian, Kamran Ghaedi, Ardeshir Talebi, Mansoureh Azadeh, Elnaz Dehdashtian · October 15, 2026
Background:
Gastric cancer is one of the most significant reasons for cancer-related death. miR-146a is one of the dysregulated factors associated with gastric tumorigenesis. However, deregulation of this microRNA (miRNA) has become controversial. Moreover, the inflammation-mediating role of this miRNA implies that miR-146a might be dysregulated by gastric cancer-related pathogens, such as Helicobacter pylori. However, the dysregulation of miR-146a in H. pylori-infected gastric tumors has not been widely studied.
Objectives:
We aimed to analyze the expression level of miR-146a in gastric cancer tissues and then to assess any potential association between miR-146a and H. pylori infection and other clinical characteristics.
Materials and Methods:
miR-146a expression level was quantitatively studied by reverse transcription quantitative polymerase chain reaction, in 144 fresh tissues including 44 normal and …