Evaluation of the expression of LINCOO475 and FOXO1 genes as tumor suppressor genes in breast cancer: Correlation of bioinformatics tools and experimental ...
This study investigates the association between LINC00475, a p53-regulated lncRNA, and FOXO1 expression in breast cancer using bioinformatics and microarray analyses to explore their potential roles as molecular biomarkers in breast cancer development and progression.
Farzaneh Motamedi, Mehri Khatami, Mohammad Mehdi Heidari, Mansoureh Azadeh, Negar Karami · October 25, 2026
Breast cancer is one of the most prevalent forms of malignancy in humans and is considered the most important life-threatening factor among women worldwide. Long non-coding RNAs (LncRNAs) are thought to be potential transcripts that regulate the expression of important genes in vital processes such as cell proliferation, apoptosis, survival, and oxidative stress. LINC00475 is an important lncRNA and is located on 9q22.31 and its expression is regulated by p53. FOXO1 gene is an important regulator in physiological processes such as cell maintenance and differentiation, stimulation of cell cycle arrest, and apoptosis. In this study, we focused on identifying a possible association between FOXO1 and LINC00475 expression levels in breast cancer. Bioinformatics expression and Microarray data analysis were utilized to find their potential role as novel biomarkers in breast cancer. The correlation of gene …