Enrichment Analysis of hsa-miR-320a most Related Pathways in Breast Cancer
This study used bioinformatics to identify hsa-miR-320a target genes and associated pathways. Results highlighted cancer, glioma, and MAPK signaling pathways, suggesting that hsa-miR-320a may suppress breast cancer cell growth and proliferation.
Sahar Janghorban, Pardis Saadatmand, Mansoureh Azadeh, Kamran Ghaedi, Morteza Asgari · October 15, 2026
Materials and Methods: By considering the role of hsa-miR-320a in breast cancer, for obtaining predicted targets of hsa-miR-320a, MIMAT ID of active arm was picked from miRBase database and inserted in miRWalk2. 0 database. Finally, for obtaining the most related pathways of hsa-miR-320a, the entrez IDs of predicted targets were inserted into DAVID database.
Results: Our data manifested KEGG signaling pathways “GLIOMA” and “pathway in cancer” and “MAPK signaling pathway” as the most statistical relevant pathways with hsa-miR-320a targetome.
Conclusions: Information from all of above signaling pathways indicates that microRNA targets the GRB2 gene and prevents the activation of the sos, Ras, Raf, MEK genes. Also targeting the ERK gene prevents cell growth and proliferation. According to these studies, it is predicted that hsa-miR-320a acts as a tumor suppressor microRNA that prevents the …