ESR1 single nucleotide polymorphism rs1062577 (c.* 3804T> A) alters the susceptibility of breast cancer risk in Iranian population
This study evaluated the association between ESR1 rs1062577 polymorphism and breast cancer risk in an Iranian population using Tetra-primer ARMS-PCR in 86 patients and 96 healthy controls.
Zahra Dehghan, Samira Sadeghi, Hossein Tabatabaeian, Kamran Ghaedi, Mansoureh Azadeh, Mohammad Fazilati, Fatemeh Bagheri · October 15, 2026
Objectives
Albeit single nucleotide polymorphisms related to ESR1 gene have been studied, only a number of them have been reported to be associated with breast cancer risk. rs1062577 is one of the most recent microRNA-related ESR1 SNPs; however, no study has been conducted to investigate the significance this polymorphism in Iranian population. In this study, we aimed to investigate the frequency and also the association between rs1062577 and breast cancer.
Materials and methods
rs1062577 position was genotyped by Tetra-primer ARMS-PCR in totally 182 blood specimens obtained from breast cancer patients (n = 86), and healthy blood donors (n = 96). The distribution of different genotypes was statistically analyzed in terms of the potential association between rs1062577 different alleles, breast cancer risk and clinicopathological criteria of breast cancer patients.
Results
The statistical analyses …