CD44 gene rs8193 C allele is significantly enriched in gastric cancer patients
This case-control study investigated the association between the CD44 rs8193 polymorphism and gastric cancer risk in 86 patients and 96 healthy controls. Using ASP-PCR and bioinformatic analysis, the study found that the C allele may be associated with increased gastric cancer susceptibility in the Iranian population.
Roya Mokhtarian, Hossein Tabatabaeian, Pardis Saadatmand, Mansoureh Azadeh, Negar Balmeh, Bagher Yakhchali, Kamran Ghaedi · October 18, 2026
Objective Gastric cancer is a multifactorial disease. In addition to environmental factors, many genes are involved in this malignancy. One of the genes associated with gastric cancer is CD44 gene and its polymorphisms. CD44 gene plays role in regulating cell survival, growth and mobility. The single nucleotide polymorphism (SNP) rs8193, located in the CD44 gene, has not been studied in gastric cancer patients of the Iranian population. The present study aims to study this polymorphism in 86 gastric cancer patients and 96 healthy individuals. Materials and Methods In this cross-sectional case-control study, rs8193 polymorphism was genotyped by allele specific primer polymerase chain reaction (ASP-PCR) technique. The obtained data were statistically analyzed. To find the potential mechanism of action, rs8193 was bioinformatically investigated. Results rs8193 C allele played a risk factor role for gastric cancer …