Decreased expression level of long non-coding RNA CCAT1, was observed in breast cancer tissue of an Isfahanian population (Iran)
This study assessed CCAT1 lncRNA expression in 74 paired breast cancer and normal tissue samples from Isfahan, Iran, using qRT-PCR. CCAT1 expression was significantly reduced in tumor tissues, suggesting its potential as a biomarker for breast cancer in this population.
Mansoureh Azadeh, Ali Salehzadeh, Kamran Ghaedi, Soheila Talesh Sasani · October 20, 2026
Breast Cancer (BC) is known as common neoplasia mostly in women. Long non-coding RNAs (LncRNAs) are considered as vital effective pathological regulators in cancers. The present study has been done to find the relation between BC and CCAT1 (colon cancer-associated transcript-1 RNA) which is situated in Chromosome 8, as known BC biomarkers. This LncRNA was evaluated in Isfahan, Iran Population. Since it has presented a significant decrease of expression in BC tissue, it may be considered as a great deal of potential to be a biomarker for this population. Quantitative real-time PCR (polymerase chain reaction) was utilized to analyze the expression levels of CCAT1on 74 pairs of tumor-normal breast tissues of BC patients. For statistical analysis, the Genex, R, and Graph prism8 software were used. An Independent student t-test was done to show a significant variation of groups. Based on statistical …