Quantitative Expression of SFN, lncRNA CCDC18‐AS1, and lncRNA LINC01343 in Human Breast Cancer as the Regulator Biomarkers in a Novel ceRNA Network …
Bioinformatics identified a potential breast cancer ceRNA network involving CCDC18-AS1, LINC01343, miR-4462, and SFN. Expression analysis by qRT-PCR in 24 paired breast cancer and normal tissues investigated their potential roles in tumor development.
Mehrnoush Rishehri, Tahereh Etemadi, Leila Pisheh, Ghazaleh Koufigar, Mansoureh Azadeh · October 20, 2026
Breast cancer (BC) is one of the leading cancers in the world, which has become an increasing serious problem. In this context, reports demonstrate that some long noncoding RNAs (lncRNAs) play significant regulatory roles in breast tumorigenesis and BC progression via various pathways and act as endogenous RNAs. Finding their dysregulation in cancer and evaluating their interaction with other molecules, such as short noncoding RNAs “microRNA (miRNAs)” as well as various genes, are the most important parts in cancer diagnostics. In this study, after performing GSEA and microarray analysis on the GSE71053 dataset, a new ceRNA network of CCDC18‐AS1, LINC01343, hsa‐miR4462, and SFN in BC was detected by bioinformatics analysis. Therefore, the expression of SFN, CCDC18‐AS1, and LINC01343 was quantitatively measured in 24 BC and normal paired tissues using qRT‐PCR. CCDC18‐AS1 …