Unveiling Novel Regulatory Mechanisms of BEX1 in Breast, Gastric, and Colorectal Cancer via a Systems Biology Approach: The Roles of lncRNAs COLCA1 and ...
This study investigated BEX1 regulatory networks in breast, gastric, and colorectal cancers using public datasets and bioinformatics tools. BEX1 expression, survival associations, and interactions with lncRNAs, miRNAs, and proteins were analyzed to identify potential cancer biomarkers and therapeutic targets.
Mohammadreza Rezaei, Parnian Salehipour, Mehrnoosh Tavakoli, Maryam Mousavi, Shima Asgari, Dorsan Vatani, Seyedeh Saba Hosseinipouya, Younes Poudineh, Mohammad Rezaei, Seyedeh Zahra Shirdeli, Reza Ghelich, Mansoureh Azadeh · October 25, 2026
Background
This study aimed to explore novel regulatory networks involving the BEX1 gene and its interaction with non-coding RNAs (ncRNAs) in breast cancer (BC), gastric cancer (GC), and colorectal cancer (CRC). BEX1 has been linked to tumor suppression, but its role in signaling pathways and its interactions with regulatory RNAs in these cancers has not been fully elucidated.
Methods
High-throughput microarray datasets (GSE10810, GSE54129, and GSE208099) were analyzed to investigate BEX1 expression in breast cancer, gastric cancer, and colorectal cancer. The expression analysis and survival outcomes for BEX1 and selected lncRNAs were validated using the ENCORI platform. Regulatory interactions of BEX1 with proteins and microRNAs were identified using STRING and miRWalk, respectively, while lncRNA interactions were examined through lncRRIsearch. Final validation of differential …